Short term oral estriol treatment restores normal premenopausal vaginal flora to elderly women

Citation
T. Yoshimura et H. Okamura, Short term oral estriol treatment restores normal premenopausal vaginal flora to elderly women, MATURITAS, 39(3), 2001, pp. 253-257
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Medicine","Medical Research General Topics
Journal title
MATURITAS
ISSN journal
0378-5122 → ACNP
Volume
39
Issue
3
Year of publication
2001
Pages
253 - 257
Database
ISI
SICI code
0378-5122(20010928)39:3<253:STOETR>2.0.ZU;2-I
Abstract
Objective: Estriol is an estrogen with considerably weaker stimulatory effe cts on endometrial proliferation than estradiol. A study was conducted to d etermine the effects of oral estriol on vaginal flora and endometrial thick ness. Methods: Fifty-nine postmenopausal women (50-75 years of age), compla ining of pruritus or vaginal discharge. participated in the study. Vaginal flora and endometrial thickness were evaluated before treatment and after r eceiving oral estriol (2 mg/day) for 14 days. Results: Prior to treatment, lactobacilli were found in vaginal cultures from only six of the 59 study p articipants, whereas after treatment, the vaginal flora of 27 women showed a presence of lactobacilli (P < 0.0001). Endometrial thickness exceeded 5 m m in only five cases. No side effects were reported. Conclusion: Estriol, w hich has little effect on the endometrium, has the potential to be highly u seful for the treatment of atrophic vaginitis. (C) 2001 Elsevier Science Ir eland Ltd. All rights reserved.