Intraoperative neurophysiologic monitoring requires information on the effe
cts of anesthetic drugs because these drugs can directly alter evoked poten
tials, thus interfering with monitoring. We report on our evaluation of the
effect of the recently introduced alpha (2)-adrenergic agonist, dexmedetom
idine, on the somatosensory evoked potentials in two patients undergoing ce
rvico-occipital fusion. Our results suggest that, although dexmedetomidine
can affect the later cortical peaks of somatosensory evoked potentials (SSE
Ps), consistent and reproducible potentials can be recorded.