Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B

Citation
Dl. Jack et al., Mannose-binding lectin regulates the inflammatory response of human professional phagocytes to Neisseria meningitidis serogroup B, J INFEC DIS, 184(9), 2001, pp. 1152-1162
Citations number
62
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
JOURNAL OF INFECTIOUS DISEASES
ISSN journal
0022-1899 → ACNP
Volume
184
Issue
9
Year of publication
2001
Pages
1152 - 1162
Database
ISI
SICI code
0022-1899(20011101)184:9<1152:MLRTIR>2.0.ZU;2-W
Abstract
The influence of the innate immune protein mannose-binding lectin (MBL) on the response of human phagocytes to Neisseria meningitidis was investigated . MBL increased the association of killed meningococci with neutrophils, mo nocytes, and macrophages by increasing the proportion of cells that recogni zed bacteria. MBL down-regulated the normal change in expression of the leu kocyte adhesion molecules CD11b and CD62L. In an ex vivo model, the additio n of MBL to the blood of MBL-deficient donors influenced the production of monocyte-derived inflammatory cytokines. The addition of high concentration s of MBL (>6 mug/mL) profoundly decreased the production of interleukin (IL )-6, IL-1 beta, and tumor necrosis factor-alpha by monocytes in response to meningococci, whereas lower concentrations enhanced the production of IL-6 and IL-1. These results suggest that MBL not only is involved in complemen t activation but also is a potent regulator of inflammatory pathways and, a s such, may affect the severity of meningococcal disease.