Antibiotic biosynthesis: from natural to unnatural compounds

Authors
Citation
Hg. Floss, Antibiotic biosynthesis: from natural to unnatural compounds, J IND MIC B, 27(3), 2001, pp. 183-194
Citations number
48
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
ISSN journal
1367-5435 → ACNP
Volume
27
Issue
3
Year of publication
2001
Pages
183 - 194
Database
ISI
SICI code
1367-5435(200109)27:3<183:ABFNTU>2.0.ZU;2-6
Abstract
The evolution of the field of biosynthesis from the unravelling of the mode of formation of natural products to the use of such knowledge to create ne w compounds is reviewed using examples from the author's laboratory. The di scussion focuses on the mode of operation of type II (spore pigment PKS) an d type I (rifamycin PKS) polyketide synthases and their diversion to genera te unnatural products, and on the genetics and biochemistry of deoxysugar f ormation in granaticin biosynthesis as a prerequisite to combinatorial enzy matic synthesis of unusual glycosides.