Chemical diversity in lipopeptide antifungal antibiotics

Citation
M. Hino et al., Chemical diversity in lipopeptide antifungal antibiotics, J IND MIC B, 27(3), 2001, pp. 157-162
Citations number
8
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
ISSN journal
1367-5435 → ACNP
Volume
27
Issue
3
Year of publication
2001
Pages
157 - 162
Database
ISI
SICI code
1367-5435(200109)27:3<157:CDILAA>2.0.ZU;2-B
Abstract
In the course of screening for antifungal antibiotics, we have discovered a novel series of lipopeptide compounds structurally related to, but highly superior to, echinocandin B in terms of their water solubility due to the p resence of a sulfate residue. These compounds, WF11899s, WF738s, WF14573s, WF16616 and WF22210, and their derivatives have diversity in their nuclear structures and acyl side chains. The producing strains were classified into two groups, the Coleomycetes group and the Hyphomycetes group. Compound FK 463, a derivative of WF11899A, is currently in Phase 3 clinical development as a novel antifungal antibiotic.