Myxobacteria, producers of novel bioactive substances

Authors
Citation
H. Reichenbach, Myxobacteria, producers of novel bioactive substances, J IND MIC B, 27(3), 2001, pp. 149-156
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
ISSN journal
1367-5435 → ACNP
Volume
27
Issue
3
Year of publication
2001
Pages
149 - 156
Database
ISI
SICI code
1367-5435(200109)27:3<149:MPONBS>2.0.ZU;2-A
Abstract
Myxobacteria are soil bacteria that move by gliding and have an astonishing life cycle culminating in fruiting body formation. In a research program a t the Gesellshaft fur Biotechnologische Forschung over the past 25 years th e organisms have been shown to be a rich source of potentially useful secon dary metabolites. So far about 80 different basic compounds and 450 structu ral variants have been characterized. Many of those compounds were new. It is particularly remarkable that myxobacteria specialize in mechanisms of ac tion that are very rare with other producers. Thus 20 new electron transpor t inhibitors, 10 substances that act on the cytoskeleton, four inhibitors o f nucleic acid polymerases, and one inhibitor of fungal acetyl-CoA carboxyl ase, a novel mechanism of action, have been found.