Simocyclinones: diversity of metabolites is dependent on fermentation conditions

Citation
J. Schimana et al., Simocyclinones: diversity of metabolites is dependent on fermentation conditions, J IND MIC B, 27(3), 2001, pp. 144-148
Citations number
5
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biotecnology & Applied Microbiology",Microbiology
Journal title
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
ISSN journal
1367-5435 → ACNP
Volume
27
Issue
3
Year of publication
2001
Pages
144 - 148
Database
ISI
SICI code
1367-5435(200109)27:3<144:SDOMID>2.0.ZU;2-C
Abstract
Simocyclinones, a novel group of angucyclinone antibiotics, are produced by Streptomyces antibioticus Tu 6040. The compounds show antibacterial and an titumor properties. In submerged cultivation, the production of simocyclino nes is strongly dependent on the carbon and nitrogen sources used in a chem ically defined medium. Productivity of distinct components and diversity of simocyclinone compounds are influenced by the medium composition. Four ser ies of simocyclinone compounds were detected by high-performance liquid chr omatography (HPLC) diode array detector (DAD) and HPLC electrospray ionizat ion (ESI) mass spectrometry (MS) analysis, isolated and the structures dete rmined by nuclear magnetic resonance (NMR) techniques. Under optimized cond itions, simocyclinone D8 was produced in an amount of 300 mg l(-1) and simo cyclinone C4 in a concentration up to 50 mg l(-1).