A novel serum chitinase that is expressed in bovine liver

Citation
M. Suzuki et al., A novel serum chitinase that is expressed in bovine liver, FEBS LETTER, 506(2), 2001, pp. 127-130
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FEBS LETTERS
ISSN journal
0014-5793 → ACNP
Volume
506
Issue
2
Year of publication
2001
Pages
127 - 130
Database
ISI
SICI code
0014-5793(20011005)506:2<127:ANSCTI>2.0.ZU;2-7
Abstract
Chitinases are ubiquitous chitin-fragmenting hydrolases. They are synthesiz ed by a vast array of organisms, including those not composed of chitin. He re, we describe a novel serum chitinase (chitin-binding protein b04, CBPb04 ), which is expressed in bovine liver. Although CBPb04 is secreted as an en docrine chitinase, it shows higher homology with human gastrointestinal tra ct exocrine chitinase (AMCase) than with macrophage endocrine chitinase (hu man chitotriosidase). This suggests that cows have a specific defense again st chitin-containing microorganisms. CBPb04 mRNA is expressed in hepatocyte s. This is the first report of a hepatogenic mammalian chitinase. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.