Headless flies generated by developmental pathway interference

Citation
Rj. Jiao et al., Headless flies generated by developmental pathway interference, DEVELOPMENT, 128(17), 2001, pp. 3307-3319
Citations number
54
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
DEVELOPMENT
ISSN journal
0950-1991 → ACNP
Volume
128
Issue
17
Year of publication
2001
Pages
3307 - 3319
Database
ISI
SICI code
0950-1991(200109)128:17<3307:HFGBDP>2.0.ZU;2-Q
Abstract
Ectopic expression of transcription factors in eye-antennal discs of Drosop hila strongly interferes with their developmental program. Early ectopic ex pression in embryonic discs interferes with the developmental pathway prime d by Eyeless and generates headless flies, which suggests that Eyeless is n ecessary for initiating cell proliferation and development of both the eye and antennal disc. Interference occurs through a block in the cell cycle th at for some ectopic transcription factors is overcome by D-CycE or D-Myc. L ate ectopic expression in cone cell precursors interferes with their differ entiation. We propose that this developmental pathway interference is a gen eral surveillance mechanism that eliminates most aberrations in the genetic program during development and evolution, and thus seriously restricts the pathways that evolution may take.