Bacteremia associated with live attenuated (chi)8110 Salmonella enterica serovar Typhi ISP1820 in healthy adult volunteers

Citation
Se. Frey et al., Bacteremia associated with live attenuated (chi)8110 Salmonella enterica serovar Typhi ISP1820 in healthy adult volunteers, CLIN IMMUNO, 101(1), 2001, pp. 32-37
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL IMMUNOLOGY
ISSN journal
1521-6616 → ACNP
Volume
101
Issue
1
Year of publication
2001
Pages
32 - 37
Database
ISI
SICI code
1521-6616(200110)101:1<32:BAWLA(>2.0.ZU;2-N
Abstract
Live attenuated chi 8110 Salmonella enterica serovar Typhi ISP1820 vaccine was given in a dose-escalation trial to healthy, adult volunteers. Positive stool and blood cultures were noted, but limited, as were immune responses measured by ELISA and ELISPOT. Only volunteers with bacteremia developed i mmune responses; however, no symptoms were associated with bacteremia. The vaccine was insufficiently immunogenic for use as a vaccine. It is possible that reduced survival in the gut and reduced immunogenicity may have been due to the thawing of frozen inocula immediately prior to use. (C) 2001 Aca demic Press.