Se. Frey et al., Bacteremia associated with live attenuated (chi)8110 Salmonella enterica serovar Typhi ISP1820 in healthy adult volunteers, CLIN IMMUNO, 101(1), 2001, pp. 32-37
Live attenuated chi 8110 Salmonella enterica serovar Typhi ISP1820 vaccine
was given in a dose-escalation trial to healthy, adult volunteers. Positive
stool and blood cultures were noted, but limited, as were immune responses
measured by ELISA and ELISPOT. Only volunteers with bacteremia developed i
mmune responses; however, no symptoms were associated with bacteremia. The
vaccine was insufficiently immunogenic for use as a vaccine. It is possible
that reduced survival in the gut and reduced immunogenicity may have been
due to the thawing of frozen inocula immediately prior to use. (C) 2001 Aca
demic Press.