Angiogenesis in pancreatic carcinoma - Thymidine phosphorylase expression in stromal cells and intratumoral microvessel density as independent predictors of overall and relapse-free survival

Citation
S. Fujioka et al., Angiogenesis in pancreatic carcinoma - Thymidine phosphorylase expression in stromal cells and intratumoral microvessel density as independent predictors of overall and relapse-free survival, CANCER, 92(7), 2001, pp. 1788-1797
Citations number
50
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER
ISSN journal
0008-543X → ACNP
Volume
92
Issue
7
Year of publication
2001
Pages
1788 - 1797
Database
ISI
SICI code
0008-543X(20011001)92:7<1788:AIPC-T>2.0.ZU;2-6
Abstract
BACKGROUND. Recently, the usefulness of intratumoral microvessel density (I MD) and expression of several angiogenic factors as prognostic indicators h ave been demonstrated in several human solid tumors. METHODS. One hundred four patients with pancreatic ductal adenocarcinoma we re examined retrospectively. The investigated clinicopathologic and immunoh istologic data included staining for vascular endothelial growth factor (VE GF), thymidine phosphorylase (TP), basic fibroblast growth factor (bFGF), C D34 (for calculating IMD), p53, and Ki-67. RESULTS. Multivariate analysis for both overall and relapse-free survival r evealed two independent variables, IMD and TP staining in stromal cells (TP s, P < 0.02). Whereas the frequency of hepatic metastasis was correlated si gnificantly with cytoplasmic expression of TP or bFGF in tumor cells (TPc, bFGFc), IMD, and p53 status, local recurrence was significantly more common in patients with positive staining for TPs, bFGF in stromal cells (bFGFs), and for the pM category (P < 0.05). TPc, bFGFc, vEGF, and p53 expression c orrelated with IMD (P < 0.01), although TPs and bFGFs expression did not. v EGF and IMD status correlated with p53 expression (P < 0.001), although TP, bFGF, and Ki-67 status did not. CONCLUSIONS. TPs expression and IMD were revealed to be valuable tools for predicting overall and relapse-free survival in patients with pancreatic ad enocarcinoma. Whereas TPc and bFGFc are likely to participate in hepatic me tastasis by means of their angiogenic properties, TPs and bFGFs may be rela ted to local tumor progression. Angiogenesis in human pancreatic carcinoma may be dependent on vEGF, TP, and bFGF. p53 abnormality is likely to take p art in VEGF-related angiogenesis. (C) 2001 American Cancer Society.