Cisplatin neurotoxicity in the treatment of metastatic germ cell tumour: time course and prognosis

Citation
M. Von Schlippe et al., Cisplatin neurotoxicity in the treatment of metastatic germ cell tumour: time course and prognosis, BR J CANC, 85(6), 2001, pp. 823-826
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
0007-0920 → ACNP
Volume
85
Issue
6
Year of publication
2001
Pages
823 - 826
Database
ISI
SICI code
0007-0920(20010914)85:6<823:CNITTO>2.0.ZU;2-F
Abstract
In order to ascertain the incidence and prognosis of cisplatin-induced neur otoxicity in testis cancer patients undergoing combination chemotherapy, 29 patients with metastatic disease were studied prospectively. Assessments i ncluded enquiry into neurological symptoms, measurement of sural nerve sens ory action potential and conduction velocity, and vibration threshold in th e left big toe. At the end of chemotherapy (3 to 4 cycles) only 3 out of 26 (11 %) patients had paraesthesiae, but 3 months later the proportion rose to 65%. Resolution occurred in the majority over the ensuing 12 months so t hat only 17% had persistent symptoms. None of the 11 patients treated with 3 cycles of chemotherapy had persisting symptoms. Vibration thresholds show ed a significant deterioration during chemotherapy (P = 0.032), further det erioration in the 3 months following chemotherapy (P = 0.009) and significa nt improvement between 3 and 12 months after chemotherapy (P = 0.038). Sura t nerve sensory action potentials and conduction velocities were unhelpful. (C) 2001 Cancer Research Campaign.