Adenocarcinoma arising in a transplanted pancreas

Citation
Am. Roza et al., Adenocarcinoma arising in a transplanted pancreas, TRANSPLANT, 72(6), 2001, pp. 1156-1157
Citations number
7
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TRANSPLANTATION
ISSN journal
0041-1337 → ACNP
Volume
72
Issue
6
Year of publication
2001
Pages
1156 - 1157
Database
ISI
SICI code
0041-1337(20010927)72:6<1156:AAIATP>2.0.ZU;2-Z
Abstract
Tumor transmission or de novo tumor development in the transplanted organ i s a rare event. Appreciation of the organ-specific risk factors for tumor d evelopment and careful inspection of the organ at procurement may reduce bu t not eliminate this complication. We report the first known combined kidne y-pancreas recipient who developed adenocarcinoma in the transplanted pancr eas. Molecular typing of the tumor by DNA sequencing supports donor derivat ion of the tumor. Despite cessation of immunosuppression and reconstitution of the recipient's immune response, the patient died from metastatic pancr eatic adenocarcinoma. Comparison is made to the reported outcomes after dia gnosis of renal cell carcinoma that appeared early after transplantation.