Activity and antigen levels of thrombin-activatable fibrinolysis inhibitorin plasma of patients with disseminated intravascular coagulation

Citation
R. Watanabe et al., Activity and antigen levels of thrombin-activatable fibrinolysis inhibitorin plasma of patients with disseminated intravascular coagulation, THROMB RES, 104(1), 2001, pp. 1-6
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
THROMBOSIS RESEARCH
ISSN journal
0049-3848 → ACNP
Volume
104
Issue
1
Year of publication
2001
Pages
1 - 6
Database
ISI
SICI code
0049-3848(20011001)104:1<1:AAALOT>2.0.ZU;2-8
Abstract
We measured the plasma levels of thrombin-activatable fibrinolysis inhibito r (TAFI) activity and antigen in patients with disseminated intravascular c oagulation (DIC) to examine the relationship between hypofibrinolysis and t he pathogenesis of DIC. TAFI activity and antigen levels in the plasma were both significantly low in patients with DIC. TAFI activity in plasma was c orrelated with TAFI antigen, indicating that activity and antigen correspon d well. The decrease of TAFI activity in DIC may be due to enhanced consump tion. Since the plasma thrombin-antithrombin HI complex (TAT) level was fou nd to be elevated in DIC, increase of thrombomodulin-thrombin complex gener ation is suggested in this state. TAFI activity and antigen levels were neg atively correlated with TAT and D-dimer, suggesting that the plasma levels of TAFI are reduced by thrombin generation. Since TAFI was not correlated w ith fibrinogen, plasma-alpha (2)plasmin inhibitor complex (PPIC) and tissue type plasminogen activator/plasminogen activator inhibitor-1 (tPA/PAI-1) c omplex, TAFI might be a secondary modulator of fibrinolysis. The TAFI activ ity in plasma was significantly low in patients with infection and in those with organ failure, suggesting that TAFI may play an important role in the mechanism of organ failure in DIC-associated sepsis. In brief, TAFI may pl ay an important role in the pathogenesis of DIC and organ failure. (C) 2001 Elsevier Science Ltd. All rights reserved.