Osteosarcoma as a second malignancy after treatment for neuroblastoma

Citation
A. Iwata et al., Osteosarcoma as a second malignancy after treatment for neuroblastoma, PED HEM ONC, 18(7), 2001, pp. 465-469
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics
Journal title
PEDIATRIC HEMATOLOGY AND ONCOLOGY
ISSN journal
0888-0018 → ACNP
Volume
18
Issue
7
Year of publication
2001
Pages
465 - 469
Database
ISI
SICI code
0888-0018(200110/11)18:7<465:OAASMA>2.0.ZU;2-3
Abstract
A 4-month old girl was diagnosed as having stage IV neuroblastoma of the ri ght adrenal gland. Preoperative chemotherapy was given, followed by local s urgical excision. Postoperatively, irradiation of the tumor bed and adjuvan t chemotherapy was given for 11 months. Nine years after cessation of chemo therapy, the patient developed left hip-joint pain. Biopsy of the ischium s howed chondroblastic osteosarcoma. Limb salvage surgery was performed after preoperative chemotherapy. Postoperatively, adjuvant chemotherapy was give n for 14 months. Twenty-two months after treatment for the secondary osteos arcoma, the patient has been remained in disease-free condition without any evidence of relapse. A second osteosarcoma occurring outside the radiation field after treatment for neuroblastoma is quite rare. This unusual case e mphasized the need for close monitoring for development of second malignant neoplasms in survivors of neuroblastoma even in the absence of a known pre disposing factor, such as radiation therapy.