"Fleximers". Design and synthesis of two novel split nucleosides

Citation
Kl. Seley et al., "Fleximers". Design and synthesis of two novel split nucleosides, ORG LETT, 3(20), 2001, pp. 3209-3210
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
1523-7060 → ACNP
Volume
3
Issue
20
Year of publication
2001
Pages
3209 - 3210
Database
ISI
SICI code
1523-7060(20011004)3:20<3209:"DASOT>2.0.ZU;2-B
Abstract
GRAPHICS A new class of shape-modified nucleosides is introduced. The purine heterob ases of adenosine and guanosine have been split into their imidazole and py rimidine components, thereby introducing flexibility while retaining the el ements necessary for recognition. As a consequence, these novel "fleximers" should find use as bioprobes for investigating enzyme-coenzyme binding sit es as well as nucleic acid and protein interactions. Their design and synth esis is described.