Detection of inducible nitric oxide synthase- and nitrotyrosine-positive cells in the lesions of pericarditis induced by porcine enterovirus serotype3 infection

Citation
T. Shin et al., Detection of inducible nitric oxide synthase- and nitrotyrosine-positive cells in the lesions of pericarditis induced by porcine enterovirus serotype3 infection, J VET MED S, 63(9), 2001, pp. 1017-1019
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
JOURNAL OF VETERINARY MEDICAL SCIENCE
ISSN journal
0916-7250 → ACNP
Volume
63
Issue
9
Year of publication
2001
Pages
1017 - 1019
Database
ISI
SICI code
0916-7250(200109)63:9<1017:DOINOS>2.0.ZU;2-9
Abstract
The expression of inducible nitric oxide synthase (iNOS), an enzyme that pr oduces nitric oxide, was examined in the nearts of pigs infected with porci ne enterovirus serotype 3 (PEV3). Piglets orally infected with PEV3 develop ed tremors and paralysis 3-7 days post-infection. Affected animals had peri carditis and myocarditis. There were fibrin and inflammatory cell infiltrat es (macrophages and neutrophils) in the pericardial sac and myocardium. Imm unohistochemically, the majority of inflammatory cells in the pericardial s ac were positive for iNOS and nitrotyrosine, an end product of nitric oxide . These results suggest that iNOS is upregulated in the pericardial lesion, and that increased nitric oxide production plays an important role in the development of PEV3-induced pericarditis and myocarditis.