Effect of fenofibrate on plasma concentration and urinary excretion of purine bases and oxypurinol

Citation
T. Yamamoto et al., Effect of fenofibrate on plasma concentration and urinary excretion of purine bases and oxypurinol, J RHEUMATOL, 28(10), 2001, pp. 2294-2297
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Rheumatology,"da verificare
Journal title
JOURNAL OF RHEUMATOLOGY
ISSN journal
0315-162X → ACNP
Volume
28
Issue
10
Year of publication
2001
Pages
2294 - 2297
Database
ISI
SICI code
0315-162X(200110)28:10<2294:EOFOPC>2.0.ZU;2-T
Abstract
Objective. To investigate whether fenofibrate increases the clearance of pu rine bases (hypoxanthine, xanthine, uric acid) and oxypurinol. Methods. We administered fenofibrate (150 mg) 3 times a day for 3 days, and then allopurinol (300 mg) 4 h after the last administration of fenofibrate , to 5 healthy subjects. Ten hours later, a clearance study was done. Results. Following 3 day administration of fenofibrate, fractional clearanc e of xanthine, uric acid, and oxypurinol increased by 41% (p < 0.05), 101% (p < 0.01), and 51% (p < 0.01), respectively, compared to baseline values, while the respective plasma concentrations decreased by 46% (p < 0.05), 46% (p < 0.05), and 19% (p < 0.05). Conclusion. Our results suggest that fenofibrate, fenofibric acid, or fenof ibrate derivatives can increase fractional clearance of xanthine, uric acid , and oxypurinol by acting on their common renal pathways. It is suggested that the hypouricemic effect of combination therapy using allopurinol and f enofibrate may be less than additive.