A new isoquinoline alkaloid from the marine sponge Haliclona species

Citation
Ma. Rashid et al., A new isoquinoline alkaloid from the marine sponge Haliclona species, J NAT PROD, 64(9), 2001, pp. 1249-1250
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
9
Year of publication
2001
Pages
1249 - 1250
Database
ISI
SICI code
0163-3864(200109)64:9<1249:ANIAFT>2.0.ZU;2-D
Abstract
Two isoquinoline alkaloids, including the new compound 1, were isolated fro m the cytotoxic fractions of an aqueous extract of the marine sponge Halicl ona sp. The structures of these compounds were established as 1-hydroxymeth yl-7-methoxyisoquinolin-6-ol (1) and mimosamycin (2) by conventional spectr oscopic methods and by comparison with related compounds. Mimosamycin (2) w as the principal cytotoxin with an IC50 of approximately 10 mug/mL against melanoma and ovarian human tumor cell lines.