Coumarins with monoamine oxidase inhibitory activity and antioxidative coumarino-lignans from Hibiscus syriacus

Citation
Bs. Yun et al., Coumarins with monoamine oxidase inhibitory activity and antioxidative coumarino-lignans from Hibiscus syriacus, J NAT PROD, 64(9), 2001, pp. 1238-1240
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
9
Year of publication
2001
Pages
1238 - 1240
Database
ISI
SICI code
0163-3864(200109)64:9<1238:CWMOIA>2.0.ZU;2-X
Abstract
A previously undescribed coumarin and a new coumarino-lignan, together with the known compounds scopoletin and cleomiscosins A, C, and D, have been is olated from the root bark of Hibiscus syriacus, and their structures were a ssigned on the basis of various spectral studies. The coumarin analogue and scopoletin inhibited monoamine oxidase with moderate IC50 values. The new coumarino-lignan and cleomiscosin C showed lipid peroxidation inhibitory ac tivity comparable to vitamin E.