Immunomodulatory constituents from an ascomycete, Eupenicillium crustaceum, and revised absolute structure of macrophorin D

Citation
H. Fujimoto et al., Immunomodulatory constituents from an ascomycete, Eupenicillium crustaceum, and revised absolute structure of macrophorin D, J NAT PROD, 64(9), 2001, pp. 1234-1237
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
9
Year of publication
2001
Pages
1234 - 1237
Database
ISI
SICI code
0163-3864(200109)64:9<1234:ICFAAE>2.0.ZU;2-P
Abstract
Fractionation guided by immunomodulatory activity of the EtOAc extract of t he Ascomycete Eupenicillium crustaceum has afforded two new naturally occur ring products, 4 ' -oxomacrophorin D (1) and 4 ' -oxomacrophorin A (2), as the immunosuppressive components of this fungus [1: 3-hydroxy-3-methylgluta ryl (HMG) conjugate of 2]. The structures including the absolute configurat ions of 1 and 2 have been determined on the basis of chemical correlation o f I with macrophorin D (3). The absolute configuration of the HMG moiety in 3 has been revised from 3R to 3S.