A new prenylated acridone alkaloid, 1,3,5-trihydroxy-2,8-bis(3-methylbut-2-
enyl)-10-methyl-9-acridone (1), was isolated from the stembark of Swinglea.
glutinosa, along with three known acridone alkaloids, 5-hydroxynoracronyci
ne (2), 1,3,5-trihydroxy-4-methoxy-2-(3-methylbut-2-enyl)-10-methyl-9-acrid
one (3), and 1,3,5-trihydroxy-4-methoxy-10-methylacridone (4). The isolated
alkaloids were assessed in vitro against chloroquine-sensitive and -resist
ant Plasmodium falciparum strains and for cytotoxicity using HeLa cells.