Three new sesquiterpene glycosides from Dendrobium nobile with immunomodulatory activity

Citation
Wm. Zhao et al., Three new sesquiterpene glycosides from Dendrobium nobile with immunomodulatory activity, J NAT PROD, 64(9), 2001, pp. 1196-1200
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
9
Year of publication
2001
Pages
1196 - 1200
Database
ISI
SICI code
0163-3864(200109)64:9<1196:TNSGFD>2.0.ZU;2-3
Abstract
Dendroside A (1) and dendronobilosides A and B (2 and 3), three new sesquit erpene glycosides, have been isolated from the stems of Dendrobium nobile, a plant used in Chinese traditional medicine. Their structures and stereoch emistry were determined as 10 beta ,12,14-trihdroxyalloaromadendrane 14-O-b eta -D-glucopyranoside (1), 10,12-dihydroxypicrotoxane 10,12-di-O-beta -D-g lucopyranoside (2), and 6a,10,12-trihydroxypicrotoxane 10-O-beta -D-glucopy ranoside (3), respectively, on the basis of spectroscopic and chemical meth ods. Quantum chemistry calculations were used in support of the structural determination of 1. Compounds 1 and 2 were found to stimulate the prolifera tion of murine T and B lymphocytes in vitro, while compound 3 showed inhibi tory activity in this same assay.