Cytotoxicity of rhamnosylanthraquinones and rhamnosylanthrones from Rhamnus nepalensis

Authors
Mai, LP Gueritte, F Dumontet, V Van Tri, M Hill, B Thoison, O Guenard, D Sevenet, T
Citation
Lp. Mai et al., Cytotoxicity of rhamnosylanthraquinones and rhamnosylanthrones from Rhamnus nepalensis, J NAT PROD, 64(9), 2001, pp. 1162-1168
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
9
Year of publication
2001
Pages
1162 - 1168
Database
ISI
SICI code
0163-3864(200109)64:9<1162:CORARF>2.0.ZU;2-V
Abstract
An extract of the fruits of Rhamnus nepalensis collected in Hoa Binh Provin ce, Vietnam, was cytotoxic to KB cells. A bioassay-guided fractionation led to the isolation of a series of known anthraquinones and anthrones, one ne w rhamnosylanthraquinone, 3'-O-acetylfrangulin A (8), several new rhamnosyl anthrones, the prinoidin-emodin bianthrones (9A-D), the prinoidin bianthron es (10A,B), and the rhamnepalins (11A-C). A structure-cytotoxic activity re lationship study was performed on these isolates and some semisynthetic der ivatives.