Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su

Citation
T. Nogawa et al., Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su, J NAT PROD, 64(9), 2001, pp. 1148-1152
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
9
Year of publication
2001
Pages
1148 - 1152
Database
ISI
SICI code
0163-3864(200109)64:9<1148:IASOFN>2.0.ZU;2-C
Abstract
Five new bufadienolides, 3 beta -formyloxyresibubgenin (1), 19-oxobufalin ( 2), 19-oxodesacetylcinobufagin (3), 6 alpha -hydroxycinobufagin (4), and 1 beta -hydroxybufalin (5), have been isolated together with the previously k nown bufadienolides 6-20 from the Chinese traditional drug "Ch'an Su". The structures were elucidated employing spectroscopic methods. Bufadienolides 1-5 provided significant inhibitory activity against the EB and HL-60 cance r cell lines. In addition, bufadienolide 1 was found active against the MH- 60 cancer cell line.