Dysideaprolines A-F and barbaleucamides A-B, novel polychlorinated compounds from a Dysidea species

Harrigan, GG Goetz, GH Luesch, H Yang, ST Likos, J

Gg. Harrigan et al., Dysideaprolines A-F and barbaleucamides A-B, novel polychlorinated compounds from a Dysidea species, J NAT PROD, 64(9), 2001, pp. 1133-1138

41

INGLESE

Article

Agricultural Chemistry","Pharmacology & Toxicology

JOURNAL OF NATURAL PRODUCTS

0163-3864 → ACNP

64

9

2001

1133 - 1138

ISI

0163-3864(200109)64:9<1133:DAABAN>2.0.ZU;2-D

Chemical investigation of a marine sponge, Dysidea sp., collected at Barari n Island, Philippines, has afforded the novel metabolites 1-6, proline-deri ved analogues of dysidenin (7). We have termed compounds 1-6 dysideaproline s A-F, respectively. Also isolated were compounds 8 and 9, structural analo gues of barbamide (10), a metabolite originally isolated from the cyanobact erium Lyngbya majuscula. We have termed these novel compounds barbaleucamid es A (8) and B (9). It is most probable that the compounds presented here a re actually derived from a symbiotic cyanobacterium found in close associat ion with the Dysidea sp. Structure elucidation of the isolated metabolites involved high-field 2D NMR spectroscopy including H-1-H-1 COSY, HSQC, and H MBC.