New spirostanol steroids and steroidal saponins from roots and rhizomes ofDracaena angustifolia and their antiproliferative activity

Le Tran, Q Tezuka, Y Banskota, AH Tran, QK Saiki, I Kadota, S

Q. Le Tran et al., New spirostanol steroids and steroidal saponins from roots and rhizomes ofDracaena angustifolia and their antiproliferative activity, J NAT PROD, 64(9), 2001, pp. 1127-1132

21

INGLESE

Article

Agricultural Chemistry","Pharmacology & Toxicology

JOURNAL OF NATURAL PRODUCTS

0163-3864 → ACNP

64

9

2001

1127 - 1132

ISI

0163-3864(200109)64:9<1127:NSSASS>2.0.ZU;2-B

The MeOH extract of Nam ginseng (roots and rhizomes of Dracaena angustifoli a) afforded nine new compounds, including three spirostanol sapogenins, nam ed namogenins A-C (1-3), four spirostanol saponins, named namonins A-D (4-7 ), a furostanol saponin, named namonin E (8), and a pregnan glycoside, name d namonin F (9), along with another eight known steroidal saponins (10-17). Their structures were determined on the basis of spectral analyses and che mical methods. All compounds were tested for their antiproliferative activi ty against murine colon 26-L5 carcinoma, human HT-1080 fibrosarcoma, and B- 16 BL6 melanoma cells. Compounds 4, 5, and 10 showed potent antiproliferati ve activity against HT-1080 fibrosarcoma cells, having IC50 values of 0.2, 0.3, and 0.6 muM, respectively, comparable to that of doxorubicin.