New spirostanol steroids and steroidal saponins from roots and rhizomes ofDracaena angustifolia and their antiproliferative activity

Citation
Q. Le Tran et al., New spirostanol steroids and steroidal saponins from roots and rhizomes ofDracaena angustifolia and their antiproliferative activity, J NAT PROD, 64(9), 2001, pp. 1127-1132
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
9
Year of publication
2001
Pages
1127 - 1132
Database
ISI
SICI code
0163-3864(200109)64:9<1127:NSSASS>2.0.ZU;2-B
Abstract
The MeOH extract of Nam ginseng (roots and rhizomes of Dracaena angustifoli a) afforded nine new compounds, including three spirostanol sapogenins, nam ed namogenins A-C (1-3), four spirostanol saponins, named namonins A-D (4-7 ), a furostanol saponin, named namonin E (8), and a pregnan glycoside, name d namonin F (9), along with another eight known steroidal saponins (10-17). Their structures were determined on the basis of spectral analyses and che mical methods. All compounds were tested for their antiproliferative activi ty against murine colon 26-L5 carcinoma, human HT-1080 fibrosarcoma, and B- 16 BL6 melanoma cells. Compounds 4, 5, and 10 showed potent antiproliferati ve activity against HT-1080 fibrosarcoma cells, having IC50 values of 0.2, 0.3, and 0.6 muM, respectively, comparable to that of doxorubicin.