Correlation of the apparent diffusion coefficient and the creatine level in early ischemic stroke: A comparison of different patterns by magnetic resonance

Citation
H. Rumpel et al., Correlation of the apparent diffusion coefficient and the creatine level in early ischemic stroke: A comparison of different patterns by magnetic resonance, J MAGN R I, 13(3), 2001, pp. 335-343
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging
Journal title
JOURNAL OF MAGNETIC RESONANCE IMAGING
ISSN journal
1053-1807 → ACNP
Volume
13
Issue
3
Year of publication
2001
Pages
335 - 343
Database
ISI
SICI code
1053-1807(200103)13:3<335:COTADC>2.0.ZU;2-M
Abstract
it has been reported that reduction of the apparent diffusion coefficient ( ADC) after stroke can persist for several days, after which the ADC increas es gradually to an abnormally high level. We evaluated ADC values of stroke lesions and compared the results to the cellular density of the lesion by means of the creatine (Cre) level. This two-parameter estimation is of part icular relevance in ascertaining the underlying cellular status. Lesion-to- contralateral ADC ratios (ADC.) were obtained based on diffusion-weighted e cho-planar and fast spin-echo imaging. Single-voxel localized spectroscopy was used for quantification of cerebral metabolites in infarcted regions. T heir levels were also compared to that in homotopic contralateral regions. Fifteen patients with ischemic stroke were examined at times ranging from 1 8-88 hours following the onset of symptoms. In the stroke lesion, there was a significant correlation between the ADC and the Cre level showing that t he higher the cell density the lower the ADC value. For ADC, vs. the lesion Cre concentration and the lesion-to-contralateral Cre ratio (Cre.), the st rengths of relationship were R-2 = 0.70 and 0.58, respectively. It is concl uded that ADC is a good reflection of cell density. Greatly lowered ADC val ues occur within the context of a stable cellularity. ADC and the Cre level have complementary roles in the characterization of stroke lesion with reg ard to the sequential stage. (C) 2001 Wiley-Liss, Inc.