Phosphoinositides and phagocytosis

Citation
Dj. Gillooly et al., Phosphoinositides and phagocytosis, J CELL BIOL, 155(1), 2001, pp. 15-17
Citations number
17
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
JOURNAL OF CELL BIOLOGY
ISSN journal
0021-9525 → ACNP
Volume
155
Issue
1
Year of publication
2001
Pages
15 - 17
Database
ISI
SICI code
0021-9525(20011001)155:1<15:PAP>2.0.ZU;2-U
Abstract
Phosphoinositide 3 kinases (PI3Ks)* are known as regulators of phagocytosis . Recent results demonstrate that class I and III PI3Ks act consecutively i n phagosome formation and maturation, and that their respective products, p hosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P-3) and phosphatidylinos itol 3-phosphate (PI[3]P), accumulate transiently at different stages. Phag osomes containing Mycobacterium tuberculosis do not acquire the PI(3)P-bind ing protein EEA1, which is required for phagosome maturation. This suggests a possible mechanism of how this microorganism evades degradation in phago lysosomes.