The DD genotype of angiotensin converting enzyme polymorphism is a risk factor for coronary artery disease and coronary stent restenosis in Japanese patients
I. Taniguchi et al., The DD genotype of angiotensin converting enzyme polymorphism is a risk factor for coronary artery disease and coronary stent restenosis in Japanese patients, JPN CIRC J, 65(10), 2001, pp. 897-900
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Stent implantation has decreased the incidence of restenosis after coronary
intervention, but has not eliminated it. The contribution of the angiotens
in-converting enzyme (ACE) genotype to the development of coronary artery d
isease and restenosis after coronary stenting was investigated in 67 Japane
se patients in whom 103 lesions in which stents had been successfully impla
nted were assessed by quantitative coronary angiography, before, immediatel
y after coronary stenting, and during follow-up. The distribution of the pa
tients with the DD, ID, and II genotypes was 13%, 54%, and 33%, respectivel
y. The prevalence of multivessel disease in the DD genotype was significant
ly higher (DD genotype: 78%; ID genotype: 58%; It genotype: 27%, chi (2)=8.
13, p=0.016) and the late loss in the DD genotype (1.43 +/-0.96 mm) was sig
nificantly greater (ID genotype: 0.78 +/-0.98 nun and II genotype: 0.79 +/-
0.88 mm, p <0.05 vs DD genotype). However, there was no significant differe
nce in the restenosis rate among the 3 genotypes. The present study in Japa
nese patients indicates that the DD genotype is associated with more extens
ive coronary artery disease and progression of the inward remodeling within
the stented lesion, which is primarily caused by neointimal hyperplasia.