Statistical tests of selective neutrality in the age of genomics

Authors
Citation
R. Nielsen, Statistical tests of selective neutrality in the age of genomics, HEREDITY, 86, 2001, pp. 641-647
Citations number
39
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Biology,"Molecular Biology & Genetics
Journal title
HEREDITY
ISSN journal
0018-067X → ACNP
Volume
86
Year of publication
2001
Part
6
Pages
641 - 647
Database
ISI
SICI code
0018-067X(200106)86:<641:STOSNI>2.0.ZU;2-G
Abstract
Examining genomic data for traces of selection provides a powerful tool for identifying genomic regions of functional importance. Many methods for ide ntifying such regions have focused on conserved sites. However, positive se lection may also be an indication of functional importance. This article pr ovides a brief review of some of the statistical methods used to detect sel ection using DNA sequence data or other molecular data. Statistical tests b ased on allelic distributions or levels of variability often depend on stro ng assumptions regarding population demographics. In contrast, tests based on comparisons of the level of variability in nonsynonymous and synonymous sites can be constructed without demographic assumptions. Such tests appear to be useful for identifying specific regions or specific sites targeted b y selection.