West Nile virus first appeared in the western hemisphere in 1999 in New Yor
k. Genetic analysis determined that the virus was introduced from the Medit
erranean Basin. This review discusses the establishment of West Nile virus
in the naive environment of the northeastern USA, its ecology, epizootiolog
y, pathology, prevention and prediction, as well as laboratory studies that
have been conducted to elucidate the transmission Cycle. Curr Opin Infect
Dis 14:519-525. (C) 2001 Lippincott Williams & Wilkins.