Sk. Seo et al., Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: Clinical and molecular evidence of drugresistance, CLIN INF D, 33(9), 2001, pp. E105-E108
We describe a case of CMV ventriculoencephalitis in a severely immunocompro
mised bone marrow transplant recipient who was receiving combination therap
y with ganciclovir and foscarnet for treatment of viremia and retinitis. An
alysis of sequential viral isolates recovered from the patient's cerebrospi
nal fluid suggested that disease developed because of the presence of viral
resistance and, possibly, low tissue penetration of antiviral agents.