Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: Clinical and molecular evidence of drugresistance

Citation
Sk. Seo et al., Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: Clinical and molecular evidence of drugresistance, CLIN INF D, 33(9), 2001, pp. E105-E108
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL INFECTIOUS DISEASES
ISSN journal
1058-4838 → ACNP
Volume
33
Issue
9
Year of publication
2001
Pages
E105 - E108
Database
ISI
SICI code
1058-4838(20011101)33:9<E105:CVIABM>2.0.ZU;2-N
Abstract
We describe a case of CMV ventriculoencephalitis in a severely immunocompro mised bone marrow transplant recipient who was receiving combination therap y with ganciclovir and foscarnet for treatment of viremia and retinitis. An alysis of sequential viral isolates recovered from the patient's cerebrospi nal fluid suggested that disease developed because of the presence of viral resistance and, possibly, low tissue penetration of antiviral agents.