Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus

Citation
Cd. Paddock et al., Infections with Ehrlichia chaffeensis and Ehrlichia ewingii in persons coinfected with human immunodeficiency virus, CLIN INF D, 33(9), 2001, pp. 1586-1594
Citations number
51
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL INFECTIOUS DISEASES
ISSN journal
1058-4838 → ACNP
Volume
33
Issue
9
Year of publication
2001
Pages
1586 - 1594
Database
ISI
SICI code
1058-4838(20011101)33:9<1586:IWECAE>2.0.ZU;2-A
Abstract
The clinical course and laboratory evaluation of 21 patients coinfected wit h human immunodeficiency virus (HIV) and Ehrlichia chaffeensis or Ehrlichia ewingii are reviewed and summarized, including 13 cases of ehrlichiosis ca used by E. chaffeensis, 4 caused by E. ewingii, and 4 caused by either E. c haffeensis or E. ewingii. Twenty patients were male, and the median CD4(+) T lymphocyte count was 137 cells/muL. Exposures to infecting ticks were lin ked to recreational pursuits, occupations, and peridomestic activities. For 8 patients, a diagnosis of ehrlichiosis was not considered until greater t han or equal to4 days after presentation. Severe manifestations occurred mo re frequently among patients infected with E. chaffeensis than they did amo ng patients infected with E. ewingii, and all 6 deaths were caused by E. ch affeensis. Ehrlichiosis may be a life-threatening illness in HIV-infected p ersons, and the influence of multiple factors, including recent changes in the epidemiology and medical management of HIV infection, may increase the frequency with which ehrlichioses occur in this patient cohort.