Pneumococcal conjugate vaccine serotypes of Streptococcus pneumoniae isolates and the antimicrobial susceptibility of such isolates in children with otitis media

Citation
Ml. Joloba et al., Pneumococcal conjugate vaccine serotypes of Streptococcus pneumoniae isolates and the antimicrobial susceptibility of such isolates in children with otitis media, CLIN INF D, 33(9), 2001, pp. 1489-1494
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL INFECTIOUS DISEASES
ISSN journal
1058-4838 → ACNP
Volume
33
Issue
9
Year of publication
2001
Pages
1489 - 1494
Database
ISI
SICI code
1058-4838(20011101)33:9<1489:PCVSOS>2.0.ZU;2-E
Abstract
The ability of the recently licensed 7-valent pneumococcal conjugate vaccin e to cover isolates that cause otitis media, especially drug-resistant ones , was assessed using 500 recently obtained US isolates. Of these isolates, 418 (84%) belonged to vaccine-related serogroups, whereas 82 (16%) belonged to non-vaccine-related serogroups. Serotype 3 accounted for 48 (59%) of th e non-vaccine-related serogroups. In addition, 93% of the isolates from pat ients less than or equal to3 years of age belonged to serotypes that were i ncluded in or related to the heptavalent vaccine, compared with 49% of the isolates from older patients (P=.001). Most of the isolates (98%-100%) that were resistant to the antimicrobial agents tested were covered by the hept avalent vaccine, including 95.1% of the isolates from patients <2 years of age. The 7-valent pneumococcal conjugate vaccine could therefore potentiall y provide protection against all but 1 (type 3) of the common otitis media- associated pneumococcal serogroups identified in this study as well as agai nst 98% of antibiotic-resistant isolates.