Infection with Burkholderia cepacia complex genomovars in patients with cystic fibrosis: Virulent transmissible strains of genomovar III can replace Burkholderia multivorans

Citation
E. Mahenthiralingam et al., Infection with Burkholderia cepacia complex genomovars in patients with cystic fibrosis: Virulent transmissible strains of genomovar III can replace Burkholderia multivorans, CLIN INF D, 33(9), 2001, pp. 1469-1475
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Immunology
Journal title
CLINICAL INFECTIOUS DISEASES
ISSN journal
1058-4838 → ACNP
Volume
33
Issue
9
Year of publication
2001
Pages
1469 - 1475
Database
ISI
SICI code
1058-4838(20011101)33:9<1469:IWBCCG>2.0.ZU;2-9
Abstract
Infection with Burkholderia cepacia complex in patients with cystic fibrosi s (CF) results in highly variable clinical outcomes. The purpose of this st udy was to determine if there are genomovar-specific disparities in transmi ssion and disease severity. B. cepacia complex was recovered from 62 patien ts with CF on greater than or equal to1 occasions (genomovar III, 46 patien ts; genomovar II [B. multivorans], 19 patients; genomovar IV [B. stabilis], 1 patient; genomovar V [B. vietnamiensis], 1 patient; and an unclassified B. cepacia complex strain, 1 patient). Patient-to-patient spread was observ ed with B. cepacia genomovar III, but not with B. multivorans. Genomovar II I strains replaced B. multivorans in 6 patients. Genomovar III strains were also associated with a poor clinical course and high mortality. Infection control practices should be designed with knowledge about B. cepacia comple x genomovar status; patients infected with transmissible genomovar III stra ins should not be cohorted with patients infected with B. multivorans and o ther B. cepacia genomovars.