Quantitative analysis of tenascin in chordae tendineae of human left ventricular papillary muscle with aging

Citation
I. Sato et K. Shimada, Quantitative analysis of tenascin in chordae tendineae of human left ventricular papillary muscle with aging, ANN ANATOMY, 183(5), 2001, pp. 443-448
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Experimental Biology
Journal title
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
ISSN journal
0940-9602 → ACNP
Volume
183
Issue
5
Year of publication
2001
Pages
443 - 448
Database
ISI
SICI code
0940-9602(200109)183:5<443:QAOTIC>2.0.ZU;2-K
Abstract
A computer image analysis was done to investigate the distribution of tenas cin and collagenous matrix components (collagen types I and III) in the cho rdae tendineae of the anterior cusp of the left ventricular papillary muscl e, using confocal laser scanning microscopy in both a 20s age group and an 80s-90s age group. Tenascin and the collagenous matrix components showed marked accumulation i n the 80s-90s age group with elastic fiber concentration being increased in the same region as that in the 20s age group. The highest content of inter surface layer staining with an anti-tenascin antibody and with anti-collage n type III in the inner layer was found in the 80s-90s age group. These con tent levels were low in each region in the 20s age group. The distribution and content of these extracellular matrix changes are related to the change s in mechanical performance of the cardiac muscle with age.