Pigmented epidermal cysts

Authors
Citation
T. Shet et S. Desai, Pigmented epidermal cysts, AM J DERMAT, 23(5), 2001, pp. 477-481
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Dermatology
Journal title
AMERICAN JOURNAL OF DERMATOPATHOLOGY
ISSN journal
0193-1091 → ACNP
Volume
23
Issue
5
Year of publication
2001
Pages
477 - 481
Database
ISI
SICI code
0193-1091(200110)23:5<477:PEC>2.0.ZU;2-1
Abstract
There are few reports documenting the presence of melanin or melanocytes in epidermal cysts. One hundred and twenty five epidermal cysts from Indian p atients were analyzed for the presence of melanin pigment and their sites w ere noted. A Masson's Fontana stain and inummohistochemistry for S-100 prot ein and HMB 45 was performed for localization of melanin and melanocytes wi thin the epidermal cysts. Seventy-nine (63%) of the epidermal cysts showed presence of melanin pigmen t or melanocytes to a variable extent. Melanin was not present in epidermal cysts occurring along lines of fusion of skin folds during embryonogenesis (e.g., ventral midline, inner canthus, nose, upper lip and in the distal m ost parts like leg and foot and also scrotum). Ten of the 79 epidermal cyst s showed extensive accumulation of melanin pigment and infiltration with me lanophages in the cyst wall. Four of these patients gave history of trauma and the follow-up was uneventful in two of them. Pigmentation of epidermal cysts thus follows a definite anatomic pattern an d is dependent on the natural skin color. Large amount of pigment accumulat ion within epidermal cysts occurs after cyst rupture and is not associated with hemochromatosis as was believed in the past.