Callosal commissural neurons of Dab1 deficient mutant mouse, yotari

Citation
T. Aoki et al., Callosal commissural neurons of Dab1 deficient mutant mouse, yotari, NEUROSCI RE, 41(1), 2001, pp. 13-23
Citations number
48
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE RESEARCH
ISSN journal
0168-0102 → ACNP
Volume
41
Issue
1
Year of publication
2001
Pages
13 - 23
Database
ISI
SICI code
0168-0102(200109)41:1<13:CCNODD>2.0.ZU;2-M
Abstract
The yotari mouse is an autosomal recessive mutant mouse, caused by mutation of disabled homolog 1 (Dab1) gene. The mutant mouse is recognized by unsta ble gait and tremor and by early deaths around at the time of weaning. The cyto architectures of cerebeller and cerebral cortices and hippocampal form ation of the yotari mouse are abnormal. These malformations strikingly rese mble those of reeler mouse. In the present study we examined the callosal c ommissural (CC) neurons of yotari, reeler and normal mice with the injectio n of recombinant adenovirus into the frontal area 1 (Fr1) to find some poss ible phenotypes specific for the yotari mouse. The distribution pattern of CC neurons of the yotari was similar to that of the reeler: retrogradely la beled CC neurons were seen throughout all depths of the contralateral Fr1. However, the present statistical analysis revealed that the difference of t he mean intracortical position of the CC neurons between the yotari and the reeler is significantly different (Student's t-test), suggesting that the phenotype of the yotari is clearly different from that of the reeler. (C) 2 001 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All ri ghts reserved.