The yotari mouse is an autosomal recessive mutant mouse, caused by mutation
of disabled homolog 1 (Dab1) gene. The mutant mouse is recognized by unsta
ble gait and tremor and by early deaths around at the time of weaning. The
cyto architectures of cerebeller and cerebral cortices and hippocampal form
ation of the yotari mouse are abnormal. These malformations strikingly rese
mble those of reeler mouse. In the present study we examined the callosal c
ommissural (CC) neurons of yotari, reeler and normal mice with the injectio
n of recombinant adenovirus into the frontal area 1 (Fr1) to find some poss
ible phenotypes specific for the yotari mouse. The distribution pattern of
CC neurons of the yotari was similar to that of the reeler: retrogradely la
beled CC neurons were seen throughout all depths of the contralateral Fr1.
However, the present statistical analysis revealed that the difference of t
he mean intracortical position of the CC neurons between the yotari and the
reeler is significantly different (Student's t-test), suggesting that the
phenotype of the yotari is clearly different from that of the reeler. (C) 2
001 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All ri
ghts reserved.