Changes of beta-actin mRNA expression in canine vasospastic basilar arteryafter experimental subarachnoid hemorrhage

Citation
H. Ohkuma et al., Changes of beta-actin mRNA expression in canine vasospastic basilar arteryafter experimental subarachnoid hemorrhage, NEUROSCI L, 311(1), 2001, pp. 9-12
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROSCIENCE LETTERS
ISSN journal
0304-3940 → ACNP
Volume
311
Issue
1
Year of publication
2001
Pages
9 - 12
Database
ISI
SICI code
0304-3940(20010921)311:1<9:COBMEI>2.0.ZU;2-G
Abstract
The aim of this study was to investigate whether vascular remodeling occurs during cerebral vasospasm after subarachnoid hemorrhage (SAH). Beta-actin mRNA expression and structural change of its 3 ' untranslated region (UTR) which are considered a non-specific marker for vascular remodeling, were ex amined by Northern analysis and polymerase chain reaction analysis in a can ine basilar artery after experimental SAH. The changes in the area of tunic a media in the basilar artery were also examined histopathologically. Incre ased beta-actin mRNA expression and its structural changes of 3 ' UTR in th e vasospastic basilar artery were markedly seen 7 and 14 days after SAH acc ompanied by increased area of tunica media in the basilar artery. The resul ts suggest that vascular remodeling occurs and takes part in the luminal na rrowing during cerebral vasospasm. (C) 2001 Elsevier Science Inc.. All righ ts reserved.