Impaired delay but normal trace eyeblink conditioning in PLC beta 4 mutantmice

Citation
Y. Kishimoto et al., Impaired delay but normal trace eyeblink conditioning in PLC beta 4 mutantmice, NEUROREPORT, 12(13), 2001, pp. 2919-2922
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
0959-4965 → ACNP
Volume
12
Issue
13
Year of publication
2001
Pages
2919 - 2922
Database
ISI
SICI code
0959-4965(20010917)12:13<2919:IDBNTE>2.0.ZU;2-Q
Abstract
To elucidate the functional role of phospholipase C beta4 (PLC beta4), whic h is highly expressed in the Purkinje cells of the rostral cerebellum, cere bellar long-term depression (LTD) and delay and trace eyeblink conditioning were investigated in PLC beta4-deficient mice. Rostral cerebellar LTD and delay eyeblink conditioning were severely impaired, whereas trace eyeblink conditioning was not. These results indicate that PLC beta4 is essential fo r LTD in the rostral cerebellum and delay conditioning, but not trace condi tioning. Rostral cerebellar LTD may be required as a neural substrate for d elay conditioning, but is not required for trace conditioning. NeuroReport 12:2919-2922 (C) 2001 Lippincott Williams & Wilkins.