Novel flow injection strategies for study and control of matrix interferences by inductively coupled plasma time-of-flight mass spectrometry

Citation
Dm. Mcclenathan et al., Novel flow injection strategies for study and control of matrix interferences by inductively coupled plasma time-of-flight mass spectrometry, J ANAL ATOM, 16(9), 2001, pp. 987-990
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
ISSN journal
0267-9477 → ACNP
Volume
16
Issue
9
Year of publication
2001
Pages
987 - 990
Database
ISI
SICI code
0267-9477(200109)16:9<987:NFISFS>2.0.ZU;2-L
Abstract
Inductively coupled plasma time-of-flight mass spectrometry is ideally suit ed for use with flow injection because of its virtually simultaneous multi- elemental and multi-isotope capabilities. Here, novel flow injection strate gies are employed for characterizing matrix interferences, as a diagnostic tool for detecting interferences and as a method for calculating the diluti on factors necessary to overcome interferences. Gradient dilution flow inje ction allows rapid characterization of interferences and avoids problems th at arise in steady-state evaluations, such Lis orifice clogging and baselin e drift. Unfortunately, more severe matrix effects are obtained with this t echnique than in steady-state experiments. In addition, by calculating anal yte ratios across the flow injection profile, it is possible to diagnose in terference effects as well as to determine the dilution factors necessary f or alleviating the interference. However, at this time, this ratio techniqu e is not completely effective, as it is limited by element-specific dispers ion Curves. Unlike conventional interference approaches that are often time -consuming, these methods offer efficient alternatives for evaluating and p ossibly avoiding matrix effects.