High preoperative plasma D-dimer level is associated with advanced tumor stage and short survival after curative resection in patients with colorectal cancer

Citation
M. Oya et al., High preoperative plasma D-dimer level is associated with advanced tumor stage and short survival after curative resection in patients with colorectal cancer, JPN J CLIN, 31(8), 2001, pp. 388-394
Citations number
31
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
ISSN journal
0368-2811 → ACNP
Volume
31
Issue
8
Year of publication
2001
Pages
388 - 394
Database
ISI
SICI code
0368-2811(200108)31:8<388:HPPDLI>2.0.ZU;2-S
Abstract
Background: An elevated plasma D-dimer level indicates activation of coagul ation and fibrinolysis. Previous studies demonstrated that the preoperative plasma D-dimer level correlates with tumor stage in patients with colorect al cancer. This study examined the relationship between preoperative plasma D-dimer level and both pathological findings and TNM classification and ex amined the prognostic significance of preoperative plasma D-dimer level. Methods: Preoperative plasma D-dimer levels were measured in 93 patients wh o underwent curative resection of colorectal cancer and 40 patients with be nign colorectal diseases other than inflammatory bowel disease. The results were analyzed for correlations between preoperative plasma D-dimer levels in patients with colorectal cancer and pathological findings, TNM classific ation and postoperative survival. Results: Preoperative plasma D-dimer levels were significantly higher in pa tients with colorectal cancer than in patients with benign colorectal disea ses. Plasma D-dimer levels were higher in patients with tumors that were re latively large, had relatively deep wall penetration and were at a relative ly advanced TNM stage. Higher preoperative plasma D-dimer levels were signi ficantly associated with shorter postoperative overall survival. Results of analysis with a multivariate proportional hazard model suggested that preo perative plasma D-dimer level was the third strongest prognostic factor; ex ceeded in importance only by lymph node status and preoperative carcinoembr yonic antigen level. Conclusions: Elevated plasma D-dimer levels in patients with colorectal can cer are associated with relatively advanced tumor stage and short postopera tive survival after curative resection. It appears that measurement of preo perative D-dimer level would be useful in the preoperative diagnosis of tum or stage and prediction of postoperative survival.