Transition metal complexes of two new imino-dihydroxamic acids

Citation
Ma. Santos et al., Transition metal complexes of two new imino-dihydroxamic acids, INORG CHIM, 321(1-2), 2001, pp. 42-48
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
INORGANICA CHIMICA ACTA
ISSN journal
0020-1693 → ACNP
Volume
321
Issue
1-2
Year of publication
2001
Pages
42 - 48
Database
ISI
SICI code
0020-1693(20010910)321:1-2<42:TMCOTN>2.0.ZU;2-7
Abstract
Two new iminodihydroxamic acids [N-benzyl-iminobis(propionohydroxamic acid) and N-benzyl-iminobis(butyrohydroxamic acid)] were prepared and studied as specific binders for the transition M2+ ions due to their potential intere st as inhibitors of metalloproteinases. Their architecture is based on alip hatic backbones, as spacers connecting two hydroxamate chelating units, wit h an N-benzyl group inserted in that skeleton to simulate the protein lipop hilic subset. Herein, we first report the synthetic procedure that basicall y involves the formation of the corresponding intermediates with two nitril e groups, which were then converted to the CONHOH moieties. Then, the acid- base and the chelating properties of these ligands towards Cu2+, Ni2+ and Z n2+ ions, studied by potentiometric and spectrophotometric techniques, are described. Both the ligands form quite stable complexes with these metal io ns, presenting a preferential M2+ coordination to the hydroxamate over the amine groups, according to the order Zn2+ greater than or equal to Ni2+ > C u2+. (C) 2001 Elsevier Science B.V. All rights reserved.