Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells

Citation
D. Dinev et al., Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells, EMBO REP, 2(9), 2001, pp. 829-834
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Molecular Biology & Genetics
Journal title
EMBO REPORTS
ISSN journal
1469-221X → ACNP
Volume
2
Issue
9
Year of publication
2001
Pages
829 - 834
Database
ISI
SICI code
1469-221X(200109)2:9<829:ESRK5(>2.0.ZU;2-L
Abstract
Extracellular signal regulated kinase 5 (ERK5) is a novel member of the mit ogen-activated protein kinase (MAPK) family with a poorly defined physiolog ical function. Since ERK5 and its upstream activator MEK5 are abundant in s keletal muscle we examined a function of the cascade during muscle differen tiation. We show that ERK5 is activated upon induction of differentiation i n mouse myoblasts and that selective activation of the pathway results in p romoter activation of differentiation-specific genes. Moreover, myogenic di fferentiation is completely blocked when ERK5 expression is inhibited by an tisense RNA. Thus, we conclude that the MEK5/ERK5 MAP kinase cascade is cri tical for early steps of muscle cell differentiation.