H. Yamada et al., Sequence-dependent antitumor efficacy of combination chemotherapy with nedaplatin, a newly developed platinum, and paclitaxel, CANCER LETT, 172(1), 2001, pp. 17-25
We evaluated the sequence dependency of antitumor efficacy and toxicity in
combination therapy of nedaplatin (NDP) with paclitaxel (TXL) against Lewis
lung carcinoma. The sequential administration of NDP prior to TXL (NT ther
apy) resulted in severe body weight loss followed by frequent toxic death o
f mice. In contrast, the sequential dosing of TXL prior to NDP (TN therapy)
resulted in synergistically enhanced inhibition of tumor growth with less
toxicity compared with the NT therapy. Comparing the antitumor activity of
NDP plus TXL with that of cisplatin (CDDP) plus TXL or carboplatin (CBDCA)
plus TXL, the combination effect of NDP plus TXL was significantly higher t
han that of CDDP plus TXL or CBDCA plus TXL. These results indicate that th
e TN therapy may have significant potential in clinical use. (C) 2001 Elsev
ier Science Ireland Ltd. All rights reserved.