Sequence-dependent antitumor efficacy of combination chemotherapy with nedaplatin, a newly developed platinum, and paclitaxel

Citation
H. Yamada et al., Sequence-dependent antitumor efficacy of combination chemotherapy with nedaplatin, a newly developed platinum, and paclitaxel, CANCER LETT, 172(1), 2001, pp. 17-25
Citations number
39
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
0304-3835 → ACNP
Volume
172
Issue
1
Year of publication
2001
Pages
17 - 25
Database
ISI
SICI code
0304-3835(20011022)172:1<17:SAEOCC>2.0.ZU;2-X
Abstract
We evaluated the sequence dependency of antitumor efficacy and toxicity in combination therapy of nedaplatin (NDP) with paclitaxel (TXL) against Lewis lung carcinoma. The sequential administration of NDP prior to TXL (NT ther apy) resulted in severe body weight loss followed by frequent toxic death o f mice. In contrast, the sequential dosing of TXL prior to NDP (TN therapy) resulted in synergistically enhanced inhibition of tumor growth with less toxicity compared with the NT therapy. Comparing the antitumor activity of NDP plus TXL with that of cisplatin (CDDP) plus TXL or carboplatin (CBDCA) plus TXL, the combination effect of NDP plus TXL was significantly higher t han that of CDDP plus TXL or CBDCA plus TXL. These results indicate that th e TN therapy may have significant potential in clinical use. (C) 2001 Elsev ier Science Ireland Ltd. All rights reserved.