Effects of a new antiallergic drug, VUF-K-8788, on infiltration of lung parenchyma by eosinophils in guinea pigs and eosinophil-adhesion to human umbilical vein endothelial cells (HUVEC)

Citation
T. Takizawa et al., Effects of a new antiallergic drug, VUF-K-8788, on infiltration of lung parenchyma by eosinophils in guinea pigs and eosinophil-adhesion to human umbilical vein endothelial cells (HUVEC), BIOL PHAR B, 24(10), 2001, pp. 1127-1132
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
0918-6158 → ACNP
Volume
24
Issue
10
Year of publication
2001
Pages
1127 - 1132
Database
ISI
SICI code
0918-6158(200110)24:10<1127:EOANAD>2.0.ZU;2-H
Abstract
Airway inflammation and reversible airway obstruction are hallmarks of bron chial asthma. In this study, we investigated the effects of a new antialler gic drug, 7-{3-[4-(2-quinolinylmethyl)-1-piperazinyl]-propoxy}-2,3-dihydro- 4H-1,4-benzothiazin-3-one (VUF-K-8788), on histopathological changes in lun g parenchyma of guinea pigs during late-phase asthmatic reaction (LAR), and on eosinophil-adhesion to human umbilical vein endothelial cells (HUVEC). Repeated exposure to ovalbumin of sensitized guinea pigs induced inflammato ry phenomena such as hyperplasia of airway epithelial cells, perivascular e dema and infiltration of lung parenchyma by eosinophils. VUF-K-8788 inhibit ed these histopathological phenomena at 10 mg/kg p.o. Moreover, the eosinop hil-adherence to HUVEC was inhibited by VUF-K-8788 at the concentration of 10-30 muM. In conclusion, this inhibitory effect of VUF-K-8788 on eosinophi l-adherence might contribute to the prevention of LAR and infiltration by e osinophils in the experimental asthmatic model in guinea pigs.