Sizable glomus tumors with cystic changes in the ankle are extremely uncomm
on. This paper describes painless glomus tumors with cystic changes arising
in the ankle of a 22-year-old woman. At the age of 14, a painless mass was
noticed on the lateral side of the left ankle, and at age 21, another mass
appeared on the medial side of the same ankle. Magnetic resonance imaging
(MRI) and computed tomography (CT) scanning revealed 4.5 x 4.0 cm and 2.0 x
2.0 cm sized masses on the medial side and a 3.0 x 4.0 cm sized cystic mas
s on the lateral side of the ankle. The tumors were removed en bloc. Micros
copically, the tumor consisted of perivascularly arranged cells with punche
d-out, round, and regular nuclei. Immunohistochemically, the tumor cells ex
pressed SMA and HHF-35, indicating smooth muscle cell characters. The patie
nt had no recurrence at 2 years after surgery.