Endocervical adenomyoma - A case report with histochemical and immunohistochemical studies

Citation
Y. Mikami et al., Endocervical adenomyoma - A case report with histochemical and immunohistochemical studies, APMIS, 109(7-8), 2001, pp. 546-550
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research General Topics
Journal title
APMIS
ISSN journal
0903-4641 → ACNP
Volume
109
Issue
7-8
Year of publication
2001
Pages
546 - 550
Database
ISI
SICI code
0903-4641(200107/08)109:7-8<546:EA-ACR>2.0.ZU;2-F
Abstract
We report a case of adenomyoma of endocervical type arising in a 44-year-ol d female. Grossly, a well-circumscribed tumor protruding from the right sid e of the uterine cervix was seen which was assumed to be an ovarian tumor b y imaging studies carried out preoperatively. The tumor was composed of a m ixture of proliferating glands of endocervical type and fascicles of smooth muscle cells. There was no distinct nuclear anaplasia in the proliferating glands, there were no architectural abnormalities, and there was no eviden ce of destructive stromal invasion such as desmoplasia. Minimal deviation a denocarcinoma, which shows a gastric phenotype with immunoreactivity for M- GGMC-1 and predominantly PAS-positive neutral mucin, was, a serious diagnos tic possibility, but the lesion was well-circumscribed, cytologic and archi tectural abnormalities were absent, and staining for M-GGMC-1 was negative, which suggested a diagnosis of endocervical adenomyoma. An increased Ki-67 labeling index by up to 20%, the presence of predominantly PAS-positive ne utral mucin, and membranous immunoreactivity for CEA in limited areas were diagnostic pitfalls, which could lead to an erroneous diagnosis of minimal deviation adenocarcinoma of the uterine cervix. Therefore, the results of t hese ancillary techniques should be interpreted with caution and combined w ith gross and light microscopic features.