Randomized clinical study of nitazoxanide compared to metronidazole in thetreatment of symptomatic giardiasis in children from Northern Peru

Citation
Jj. Ortiz et al., Randomized clinical study of nitazoxanide compared to metronidazole in thetreatment of symptomatic giardiasis in children from Northern Peru, ALIM PHARM, 15(9), 2001, pp. 1409-1415
Citations number
35
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology,"da verificare
Journal title
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
ISSN journal
0269-2813 → ACNP
Volume
15
Issue
9
Year of publication
2001
Pages
1409 - 1415
Database
ISI
SICI code
0269-2813(200109)15:9<1409:RCSONC>2.0.ZU;2-Y
Abstract
Background: Enteric infection by Giardia intestinalis is a common cause of diarrhoea world-wide and a significant cause of morbidity in children. Aim: To compare the efficacy and safety of nitazoxanide and metronidazole i n the treatment of diarrhoea caused by G. intestinalis in children. Methods: A total of 110 children presenting with diarrhoea caused by G. int estinalis were randomized to treatment with either a 3-day course of nitazo xanide (100 mg b.d., age range 2-3 years; 200 mg b.d., age range 4-11 years ) or a 5-day course of metronidazole (125 mg b.d., age range 2-5 years; 250 mg b.d., age range 6-11 years). The patients were followed-up for a determ ination of clinical response 7 days after the initiation of treatment, and two subsequent stool samples were collected for parasitological examination . Results: Diarrhoea had resolved in 47 children out of SS (85%) in the nitaz oxanide treatment group before the day 7 follow-up visit, compared to 44 ou t of 55 (80%) for metronidazole. Diarrhoea resolved within 4 days in most c ases. Only mild, transient adverse events were reported. Conclusions: A 3-day course of nitazoxanide suspension is as efficacious as a standard 5-day course of metronidazole suspension in treating giardiasis in children.