Background: Enteric infection by Giardia intestinalis is a common cause of
diarrhoea world-wide and a significant cause of morbidity in children.
Aim: To compare the efficacy and safety of nitazoxanide and metronidazole i
n the treatment of diarrhoea caused by G. intestinalis in children.
Methods: A total of 110 children presenting with diarrhoea caused by G. int
estinalis were randomized to treatment with either a 3-day course of nitazo
xanide (100 mg b.d., age range 2-3 years; 200 mg b.d., age range 4-11 years
) or a 5-day course of metronidazole (125 mg b.d., age range 2-5 years; 250
mg b.d., age range 6-11 years). The patients were followed-up for a determ
ination of clinical response 7 days after the initiation of treatment, and
two subsequent stool samples were collected for parasitological examination
Results: Diarrhoea had resolved in 47 children out of SS (85%) in the nitaz
oxanide treatment group before the day 7 follow-up visit, compared to 44 ou
t of 55 (80%) for metronidazole. Diarrhoea resolved within 4 days in most c
ases. Only mild, transient adverse events were reported.
Conclusions: A 3-day course of nitazoxanide suspension is as efficacious as
a standard 5-day course of metronidazole suspension in treating giardiasis